DNA PROFILING

Human DNA

ØOne copy of Homo sapiens DNA contains three billion base pairs located on 23 chromosomes. It codes for approximately 50,000 genes.

ØSo, only a few percent of our DNA actually codes for protein!

1.DNA that codes for protein. Exons 2-3{7bda82c1e6998b9ed8f6e0f52f1ca5ed9d6da876adcfbd0d890c6e0d88340190}

2.Non-coding single copy. Intron DNA 70{7bda82c1e6998b9ed8f6e0f52f1ca5ed9d6da876adcfbd0d890c6e0d88340190}

3.Non-coding repetitive DNA. 30{7bda82c1e6998b9ed8f6e0f52f1ca5ed9d6da876adcfbd0d890c6e0d88340190}. Of this:-

  • 2/3 Randomly repetitive (or 20{7bda82c1e6998b9ed8f6e0f52f1ca5ed9d6da876adcfbd0d890c6e0d88340190} total DNA)
  • 1/3 Tandemly repetitive (or 10{7bda82c1e6998b9ed8f6e0f52f1ca5ed9d6da876adcfbd0d890c6e0d88340190} total DNA)

Randomly repetitive An interesting example of randomly repetitive DNA is the ALU Family. This is a 300bp sequence that is randomly repeated 500,000 times in our DNA! (5{7bda82c1e6998b9ed8f6e0f52f1ca5ed9d6da876adcfbd0d890c6e0d88340190} of total!)

Tandemly repetitive An example of tandemly repetitive DNA is the sequence (GGGCAGC)n. This sequence is tandemly repeated in different locations in our DNA.

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